Basic Information:

Complex ID	CMCS00106
Complex	Pml; Itpr3; Akt1; Ppp2r2b
Subunit Number	4
Membrane Contact Site	ER-MT; MT-ER
Species	Mouse
Identified PPI in BioGRID	Akt1-Ppp2r2b(LTP)

Subunit Information:

Subunit	Symbol	Uniprot ID	Subcellular location	More
subunit:1	Itpr3	P70227	ER	more
subunit:2	pml	Q60953	ER	more
subunit:3	Akt1	P31750	NA	more
subunit:4	Ppp2r2b	Q6ZWR4	NA	more

References:

Pubmed ID	21030605
DOI	10.1126/science.1189157
Description	We found that Pml, IP3R3, Akt, and PP2a colocalize in high molecular weight complexes, supporting their possible interaction in the native state.; We show that extranuclear Pml was specifically enriched at the endoplasmic reticulum (ER) and at the mitochondria-associated membranes, signaling domains involved in ER-to-mitochondria calcium ion (Ca2+) transport and in induction of apoptosis.
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