Basic Information:

Symbol	Pml
Protein Name	Protein PML
Species	Mouse
Entrez ID	18854
Uniprot ID	Q60953
Membrane Contact Site	ER-MT; MT-ER
Location (from literature)	ER
Cell line/Tissue	MEFs
Experimental Method	Low throughput experimental methods
Protein Sequence
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Complex Information:

Complex ID	Subunit of complex	Subcellular location	Species	More
CMCS00106	Pml; Itpr3; Akt1; Ppp2r2b	ER-MT; MT-ER	Mouse	more

Expression Overview of Pml:

Homology Information of Pml:

Uniprot ID	Q60953
EggNOG	KOG2177
HOGENOM	CLU_009136_1_0_1
OrthoDB	5352396at2759
TreeFam	TF336434
GeneTree	ENSGT00510000048454

References:

Pubmed ID	21030605
DOI	10.1126/science.1189157
Description	We found that Pml, IP3R3, Akt, and PP2a colocalize in high molecular weight complexes, supporting their possible interaction in the native state.; We show that extranuclear Pml was specifically enriched at the endoplasmic reticulum (ER) and at the mitochondria-associated membranes, signaling domains involved in ER-to-mitochondria calcium ion (Ca2+) transport and in induction of apoptosis.
Description of experimental evidence	The protein was validated by fura-2 measurements, aequorin measurements, luciferase measurements, western blotting, immunolocalization, immunoelectron microscopy and co-immunoprecipitation in MEFs, which regulates apoptosis at endoplasmic reticulum by modulating calcium release.
More related results