Detail Information of Protein
Basic Information:
| Symbol | Ppp2r2b |
| Protein Name | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta) |
| Species | Mouse |
| Entrez ID | 72930 |
| Uniprot ID | Q6ZWR4 |
| Membrane Contact Site |
ER-MT; MT-ER
|
| Location (from literature) | MT |
| Cell line/Tissue | MEFs; Mouse brains and retinas; RGCs; HRECs |
| Experimental Method | Low throughput experimental methods |
| Protein Sequence | |
| More related results |
Complex Information:
| Complex ID | Subunit of complex | Subcellular location | Species | More |
| CMCS00106 | Pml; Itpr3; Akt1; Ppp2r2b | ER-MT; MT-ER | Mouse | more |
Expression Overview of Ppp2r2b:
Homology Information of Ppp2r2b:
| Uniprot ID | Q6ZWR4 |
| EggNOG | KOG1354 |
| HOGENOM | CLU_021713_3_3_1 |
| OrthoDB | 397100at2759 |
| TreeFam | TF105553 |
| GeneTree | ENSGT00950000182864 |
References:
| Pubmed ID | 21030605 |
| DOI | 10.1126/science.1189157 |
| Description | We found that Pml, IP3R3, Akt, and PP2a colocalize in high molecular weight complexes, supporting their possible interaction in the native state.; We show that extranuclear Pml was specifically enriched at the endoplasmic reticulum (ER) and at the mitochondria-associated membranes, signaling domains involved in ER-to-mitochondria calcium ion (Ca2+) transport and in induction of apoptosis. |
| Description of experimental evidence | The protein was validated by fura-2 measurements, aequorin measurements, luciferase measurements, western blotting, immunolocalization, immunoelectron microscopy and co-immunoprecipitation in MEFs, which regulates apoptosis at endoplasmic reticulum by modulating calcium release. |
| More related results |
| Pubmed ID | 29785746 |
| DOI | 10.1002/pmic.201700478 |
| Description | By Andromeda search engine against the decoy UniProt-mouse database and Swiss-Prot human database, which yielded 2,808 proteins from mouse testes (mT),2,478 proteins from mouse brain (mB) and 2,155 proteins from human testes (hT). |
| Description of experimental evidence | The protein was validated by TEM and LC -MS/MS analyses in mouse brains. |
| More related results |
| Pubmed ID | 28522876 |
| DOI | 10.1038/s41598-017-02213-1 |
| Description | Using this method, 1313 non-redundant proteins were identified in the MAM. |
| Description of experimental evidence | The protein was validated by proteomic analysis, long gradient nano-reverse-phase liquid chromatography, mass spectrometry and bioinformatics analysis in RGCs, HRECs, mouse brains and retinas. |
| More related results |