Basic Information:

Symbol	Itpr3
Synonyms	IP3R3
Protein Name	Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)
Species	Mouse
Entrez ID	16440
Uniprot ID	P70227
Membrane Contact Site	ER-MT; MT-ER
Location (from literature)	ER
Cell line/Tissue	Neuro2a cells; MEFs; C57BL6 mice; Mouse testes; Mouse brains
Experimental Method	Low throughput experimental methods
Protein Sequence
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Complex Information:

Complex ID	Subunit of complex	Subcellular location	Species	More
CMCS00078	Sigmar1; Itpr3	ER-MT; MT-ER	Mouse	more
CMCS00106	Pml; Itpr3; Akt1; Ppp2r2b	ER-MT; MT-ER	Mouse	more
CMCS00107	Itpr3; Hspa9; Vdac1; Park7	ER-MT; MT-ER	Mouse	more

Expression Overview of Itpr3:

Homology Information of Itpr3:

Uniprot ID	P70227
EggNOG	KOG3533
HOGENOM	CLU_000206_1_0_1
OrthoDB	5480299at2759
TreeFam	TF312815
GeneTree	ENSGT00940000157078

References:

Pubmed ID	27821430
DOI	10.15252/emmm.201606403
Description	All these data indicate that the Sig1R activation that regulates IP3R3‐mediated intracellular Ca2+ flux at the MAM is crucial to prevent MAM disruption in motor neurons both in vitro and in vivo.
Description of experimental evidence	The protein was validated by rotarod test, immunofluorescence staining, electron microscopy, cycloheximide chase assay, co‐immunoprecipitation and neurotoxicity assay in Neuro2a cells, and the results indicate that collapse of the MAM is critical both in Sig1R ?and SOD1‐linked ALS.
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Pubmed ID	21030605
DOI	10.1126/science.1189157
Description	We found that Pml, IP3R3, Akt, and PP2a colocalize in high molecular weight complexes, supporting their possible interaction in the native state. ; We show that extranuclear Pml was specifically enriched at the endoplasmic reticulum (ER) and at the mitochondria-associated membranes, signaling domains involved in ER-to-mitochondria calcium ion (Ca2+) transport and in induction of apoptosis.
Description of experimental evidence	The protein was validated by fura-2 measurements, aequorin measurements, luciferase measurements, western blotting, immunolocalization, immunoelectron microscopy and co-immunoprecipitation in MEFs, which regulates apoptosis at endoplasmic reticulum by modulating calcium release.
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Pubmed ID	31767755
DOI	10.1073/pnas.1906565116
Description	DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-GRP75-VDAC1.
Description of experimental evidence	The protein was validated by western blotting, electron microscopy, co-immunoprecipitation assays, PLA, Blue-Native and SDS-PAGE 2D separation in C57BL6 mice, and suggests that impaired ER-mitochondria association could contribute to the pathogenesis of PD.
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Pubmed ID	29785746
DOI	10.1002/pmic.201700478
Description	By Andromeda search engine against the decoy UniProt-mouse database and Swiss-Prot human database, which yielded 2,808 proteins from mouse testes (mT),2,478 proteins from mouse brain (mB) and 2,155 proteins from human testes (hT).
Description of experimental evidence	The protein was validated by TEM and LC -MS/MS analyses in mouse testes and mouse brains.
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