Basic Information:

Complex ID	CMCS00006
Complex	ZFYVE27; FYCO1; KIF5B; RAB7A; PI(3)P
Subunit Number	5
Membrane Contact Site	ER-Endosome; Endosome-ER
Species	Human
Identified PPI in BioGRID	ZFYVE27-RAB7A(HTP: 0.02); FYCO1-KIF5B(HTP: -); FYCO1-RAB7A(HTP: 0.00)

Subunit Information:

Subunit	Symbol	Uniprot ID	Subcellular location	More
subunit:1	ZFYVE27	Q5T4F4	ER	more
subunit:2	FYCO1	Q9BQS8	Endosome	more
subunit:3	KIF5B	P33176	Endosome	more
subunit:4	RAB7A	P51149	Endosome	more

References:

Pubmed ID	25855459
DOI	10.1038/nature14359
Description	Such fusion induces outgrowth of protrusions and neurites, which requires the abilities of protrudin and FYCO1 to interact with LEs and kinesin 1.Thus, protrudin-containing ER-LE contact sites are platforms for kinesin-1 loading onto LEs, and kinesin-1-mediated translocation of LEs to the plasma membrane, fuelled by repeated ER contacts, promotes protrusion and neurite outgrowth.
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