Detail Information of Protein
Basic Information:
| Symbol | FYCO1 |
| Synonyms | ZFYVE7 |
| Protein Name | FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7) |
| Species | Human |
| Entrez ID | 79443 |
| Uniprot ID | Q9BQS8 |
| Membrane Contact Site |
ER-Endosome; Endosome-ER
|
| Location (from literature) | Endosome |
| Cell line/Tissue | HeLa cells; hTERT-RPE1 cells; HL60 cells; HEK293 cells |
| Experimental Method | Low throughput experimental methods |
| Protein Sequence | |
| More related results |
Complex Information:
| Complex ID | Subunit of complex | Subcellular location | Species | More |
| CMCS00006 | ZFYVE27; FYCO1; KIF5B; RAB7A; PI(3)P | ER-Endosome; Endosome-ER | Human | more |
Homology Information of FYCO1:
| Uniprot ID | Q9BQS8 |
| EggNOG | KOG1729 |
| HOGENOM | CLU_004445_0_0_1 |
| OrthoDB | 5394846at2759 |
| TreeFam | TF341788 |
| GeneTree | ENSGT00940000154044 |
References:
| Pubmed ID | 25855459 |
| DOI | 10.1038/nature14359 |
| Description | Here we show in human and rat cell lines that protrudin, an ER protein that promotes protrusion and neurite outgrowth, forms contact sites with late endosomes (LEs) via coincident detection of the small GTPase RAB7 and phosphatidylinositol 3-phosphate (PtdIns(3)P). These contact sites mediate transfer of the microtubule motor kinesin 1 from protrudin to the motor adaptor FYCO1 on LEs. |
| Description of experimental evidence | The protein was validated by microscopy, western blotting, GFP-trap assay in HeLa cells, HEK293 cells; hTERT-RPE1 cells and HL60 cells, and these results correlate strongly with the cooperative effects of protrudin and FYCO1 in protrusion and neurite outgrowth. |
| More related results |