Detail information of Complex
Basic Information:
| Complex ID | CMCS00175 |
| Complex | Vdac1; Itpr1; Hspa9 |
| Subunit Number | 3 |
| Membrane Contact Site |
ER-MT; MT-ER
|
| Species | Mouse |
| Identified PPI in BioGRID | / |
Subunit Information:
| Subunit | Symbol | Uniprot ID | Subcellular location | More |
| subunit:1 | Hspa9 | P38647 | MT | more |
| subunit:2 | Vdac1 | Q60932 | MT | more |
| subunit:3 | Itpr1 | P11881 | ER | more |
References:
| Pubmed ID | 30590033 |
| DOI | 10.1016/j.celrep.2018.11.094 |
| Description | GRP75 localizes in Mitochondrion-associated membranes (MAMs) and acts as a bridging molecule between the two organelles by assembling the IP3R-GRP75-VDAC complex, which is involved in the transport of Ca2+from the endoplasmic reticulum (ER) to Mitochondrion.TG2 interacts with GRP75 in mitochondria-associated membranes (MAMs). |
| More related results |
| Pubmed ID | 24947355 |
| DOI | 10.2337/db13-1751 |
| Description | Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) are functional domains between both organelles involved in Ca2+ exchange, through the voltage-dependent anion channel (VDAC)-1/glucose-regulated protein 75 (Grp75)/inositol 1,4,5-triphosphate receptor (IP3R)-1 complex, and regulating energy metabolism. |
| More related results |