Basic Information:

Complex ID	CMCS00063
Complex	Orai1; Stim1; Unc93b1
Subunit Number	3
Membrane Contact Site	ER-PM; PM-ER
Species	Mouse
Identified PPI in BioGRID	Orai1-Stim1

Subunit Information:

Subunit	Symbol	Uniprot ID	Subcellular location	More
subunit:1	CRCM1	Q8BWG9	NA	more
subunit:2	Stim1	P70302	ER; PM	more
subunit:3	Unc93b1	Q8VCW4	ER	more

References:

Pubmed ID	35065962
DOI	10.1016/j.jbc.2022.101607
Description	At these ER–PM junctions, STIM1 can trap and gate Orai1 Ca2+ channels, eliciting an influx of Ca2+ from the extracellular milieu into the cytoplasm.; UNC93B1 deficiency might impair the traffic or activity of an adapter protein to reduce STIM1–Orai1 interactions but not STIM1 recruitment.
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