Basic Information:

Symbol	CRCM1
Synonyms	Orai1; Cracm1; Tmem142a
Species	Mouse
Entrez ID	109305
Uniprot ID	Q8BWG9
Membrane Contact Site	ER-PM; PM-ER
Cell line/Tissue	mouse dendritic cells
Experimental Method	Low throughput experimental methods
Protein Sequence

Complex Information:

Complex ID	Subunit of complex	Subcellular location	Species	More
CMCS00063	Orai1; Stim1; Unc93b1	ER-PM; PM-ER	Mouse	more

Expression Overview of CRCM1:

Homology Information of CRCM1:

Uniprot ID	Q8BWG9
EggNOG	KOG4298
HOGENOM	CLU_062509_1_1_1
OrthoDB	2905973at2759
TreeFam	TF313576
GeneTree	ENSGT00390000015354

References:

Pubmed ID	35065962
DOI	10.1016/j.jbc.2022.101607
Description	At these ER–PM junctions, STIM1 can trap and gate Orai1 Ca2+ channels, eliciting an influx of Ca2+ from the extracellular milieu into the cytoplasm.; UNC93B1 deficiency might impair the traffic or activity of an adapter protein to reduce STIM1–Orai1 interactions but not STIM1 recruitment.
Description of experimental evidence	The protein was validated by immunoprecipitation, western blot analysis, PCR ,qPCR, Duolink and TIRF microscopy in mouse dendritic cells, which maintains the ER calcium sensor STIM1 in a dimeric state primed for translocation to the ER cortex.
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