Basic Information:

Complex ID	CMCS00014
Complex	MOSPD2; STARD3
Subunit Number	2
Membrane Contact Site	ER-Endosome; Endosome-ER
Species	Human
Identified PPI in BioGRID	MOSPD2-STARD3(LTP)

Subunit Information:

Subunit	Symbol	Uniprot ID	Subcellular location	More
subunit:1	MOSPD2	Q8NHP6	ER	more
subunit:2	STARD3	Q14849	Endosome	more

References:

Pubmed ID	29858488
DOI	10.15252/embr.201745453
Description	Consequently, MOSPD2 and these organelle‐bound proteins mediate the formation of contact sites between the ER and endosomes, mitochondria, or Golgi.; ll these proteins, by binding VAP proteins, are known to build contact sites between the ER and endosomes (STARD3, STARD3NL, ORP1L), mitochondria (PTPIP51), and Golgi (STARD11).
More related results

Pubmed ID	33124732
DOI	10.15252/embj.2019104369
Description	The endoplasmic reticulum possesses three major receptors, VAP‐A, VAP‐B, and MOSPD2, which interact with proteins at the surface of other organelles to build contacts; a novel type of FFATs that we named Phospho‐FFATs (illustrated here with STARD3), which strictly depend on phosphorylation to be active. Thus, phosphorylation acts as a switch mechanism to turn on the interaction between VAPs/MOSPD2 and their partners possessing a Phospho‐FFAT, and thus membrane contact site formation.
More related results