Basic Information:

Symbol	MOSPD2
Protein Name	Motile sperm domain-containing protein 2
Species	Human
Entrez ID	158747
Uniprot ID	Q8NHP6
Membrane Contact Site	ER-Endosome; Endosome-ER
Location (from literature)	ER
Cell line/Tissue	HeLa cells; HEK293T cells
Experimental Method	Low throughput experimental methods
Protein Sequence
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Complex Information:

Complex ID	Subunit of complex	Subcellular location	Species	More
CMCS00013	MOSPD2; STARD3NL	ER-Endosome; Endosome-ER	Human	more
CMCS00014	MOSPD2; STARD3	ER-Endosome; Endosome-ER	Human	more
CMCS00015	MOSPD2; OSBPL1A	ER-Endosome; Endosome-ER	Human	more
CMCS00072	MOSPD2; CERT1	ER-Endosome; Endosome-ER	Human	more

Homology Information of MOSPD2:

Uniprot ID	Q8NHP6
EggNOG	KOG1470
HOGENOM	CLU_028924_1_0_1
OrthoDB	2168468at2759
TreeFam	TF351054
GeneTree	ENSGT00390000016713

References:

Pubmed ID	29858488
DOI	10.15252/embr.201745453
Description	Consequently, MOSPD2 and these organelle‐bound proteins mediate the formation of contact sites between the ER and endosomes, mitochondria, or Golgi.; ll these proteins, by binding VAP proteins, are known to build contact sites between the ER and endosomes (STARD3, STARD3NL, ORP1L), mitochondria (PTPIP51), and Golgi (STARD11).
Description of experimental evidence	The protein was validated by immunofluorescence, colocalization analysis, SDS–PAGE, western blot, coomassie blue staining, pull‐down assays, GFP‐Trap, mass spectrometry analysis, electron microscopy and immunoprecipitation in HeLa cells and HEK293T cells.
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Pubmed ID	33124732
DOI	10.15252/embj.2019104369
Description	The endoplasmic reticulum possesses three major receptors, VAP‐A, VAP‐B, and MOSPD2, which interact with proteins at the surface of other organelles to build contacts; onventional FFATs (illustrated here with STARD11/CERT) which allow the formation of a stable complex between VAPs/MOSPD2 and thus the formation of MCSs.
Description of experimental evidence	The protein was validated by pull‐down assays, immunoprecipitation,SDS–PAGE, western blot, CIP treatment, coomassie blue staining, mass spectrometry analysis, immunofluorescence and colocalization analysis in HeLa cells.
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