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The chemical modification design module
The cm-siRNA efficiency prediction module
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Keyword:
Modifications in sense strand
Modifications in antisense strand
Position in Sense strand
Position in Antisense strand
Chemical Modification Type Reference
Cell Type:
All
Hela
Hep3B
Hepa1-6
Primary human hepatocytes
Primary Cynomolgus Monkey Hepatocytes
Huh7
Transgenic mice
HEK293A
PHH
RT-4
COS7
Primary mouse hepatocytes
HepG2
Chinese Hamster Ovary cells(CHO)
Macaca fascicularis
Be(2)C cell line
Neuro2A cell line
T98G cell
Human neuroblastoma Kelly cells(DSMZ)
Human iPSC-derived cortical neurons
CD-1 mouse gastrocnemius muscle
CD-1 mouse serum
Rat serum
Chicken embryo myoblasts
C₂C₁₂ cell
Left lobe of the crab-eating macaque liver
Right lobe of the crab-eating macaque liver
Sprague Dawley rat
Mus musculus
Primary Macaque Hepatocytes
C57BL/6 female mice
LDL Receptor Knockout Mice
Macaca mulatta
Metabolic Syndrome Monkey
ob/ob mouse model
Human APOC3 Transgenic Mouse
Hypertensive patient
The C57BL/6 mice transduced with AAV expressing human AGT
Female AGT transgenic mice
Non-human hepatocytes
RGA cell
HelaS3
Unknown cell line
Target Gene:
All
CTNNB1
INHBE
LPA
PNPLA3
APP
MAPT
MSTN
PLN
HSD17B13
MARC1
ANGPTL3
AGT
PCSK9
Modification locations:
(antisense and sense strand)
All
Sugar
Base
Phosphate
Phosphate, Base
Phosphate, Sugar
Modification Type
Target Gene
Patent ID
patent_ID
(example:
#1
#2
)
Cell Type:
All
Hela
Hep3B
Hepa1-6
Primary human hepatocytes
Primary Cynomolgus Monkey Hepatocytes
Huh7
Transgenic mice
HEK293A
PHH
RT-4
COS7
Primary mouse hepatocytes
HepG2
Chinese Hamster Ovary cells(CHO)
Macaca fascicularis
Be(2)C cell line
Neuro2A cell line
T98G cell
Human neuroblastoma Kelly cells(DSMZ)
Human iPSC-derived cortical neurons
CD-1 mouse gastrocnemius muscle
CD-1 mouse serum
Rat serum
Chicken embryo myoblasts
C₂C₁₂ cell
Left lobe of the crab-eating macaque liver
Right lobe of the crab-eating macaque liver
Sprague Dawley rat
Mus musculus
Primary Macaque Hepatocytes
C57BL/6 female mice
LDL Receptor Knockout Mice
Macaca mulatta
Metabolic Syndrome Monkey
ob/ob mouse model
Human APOC3 Transgenic Mouse
Hypertensive patient
The C57BL/6 mice transduced with AAV expressing human AGT
Female AGT transgenic mice
Non-human hepatocytes
RGA cell
HelaS3
Unknown cell line
Modification locations:
(include antisense and sense strand)
All
Sugar
Base
Phosphate
Target_Gene
(example:
#1
#2
)
Cell Type:
All
Hela
Hep3B
Hepa1-6
Primary human hepatocytes
Primary Cynomolgus Monkey Hepatocytes
Huh7
Transgenic mice
HEK293A
PHH
RT-4
COS7
Primary mouse hepatocytes
HepG2
Chinese Hamster Ovary cells(CHO)
Macaca fascicularis
Be(2)C cell line
Neuro2A cell line
T98G cell
Human neuroblastoma Kelly cells(DSMZ)
Human iPSC-derived cortical neurons
CD-1 mouse gastrocnemius muscle
CD-1 mouse serum
Rat serum
Chicken embryo myoblasts
C₂C₁₂ cell
Left lobe of the crab-eating macaque liver
Right lobe of the crab-eating macaque liver
Sprague Dawley rat
Mus musculus
Primary Macaque Hepatocytes
C57BL/6 female mice
LDL Receptor Knockout Mice
Macaca mulatta
Metabolic Syndrome Monkey
ob/ob mouse model
Human APOC3 Transgenic Mouse
Hypertensive patient
The C57BL/6 mice transduced with AAV expressing human AGT
Female AGT transgenic mice
Non-human hepatocytes
RGA cell
HelaS3
Unknown cell line
Modification locations:
(include antisense and sense strand)
All
Sugar
Base
Phosphate
Modification Type
(example:
#1
#2
)
Cell Type:
All
Hela
Hep3B
Hepa1-6
Primary human hepatocytes
Primary Cynomolgus Monkey Hepatocytes
Huh7
Transgenic mice
HEK293A
PHH
RT-4
COS7
Primary mouse hepatocytes
HepG2
Chinese Hamster Ovary cells(CHO)
Macaca fascicularis
Be(2)C cell line
Neuro2A cell line
T98G cell
Human neuroblastoma Kelly cells(DSMZ)
Human iPSC-derived cortical neurons
CD-1 mouse gastrocnemius muscle
CD-1 mouse serum
Rat serum
Chicken embryo myoblasts
C₂C₁₂ cell
Left lobe of the crab-eating macaque liver
Right lobe of the crab-eating macaque liver
Sprague Dawley rat
Mus musculus
Primary Macaque Hepatocytes
C57BL/6 female mice
LDL Receptor Knockout Mice
Macaca mulatta
Metabolic Syndrome Monkey
ob/ob mouse model
Human APOC3 Transgenic Mouse
Hypertensive patient
The C57BL/6 mice transduced with AAV expressing human AGT
Female AGT transgenic mice
Non-human hepatocytes
RGA cell
HelaS3
Unknown cell line
Modification locations:
(include antisense and sense strand)
All
Sugar
Base
Phosphate
Query for RNA sequences:
Example
Please enter DNA or RNA sequence information in FASTA format. For bulk queries, enter different sequences in line breaks.There is no need to specify the sense strand or the antisense strand.
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