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All Hela Hep3B Hepa1-6 Primary human hepatocytes Primary Cynomolgus Monkey Hepatocytes Huh7 Transgenic mice HEK293A PHH RT-4 COS7 Primary mouse hepatocytes HepG2 Chinese Hamster Ovary cells(CHO) Macaca fascicularis Be(2)C cell line Neuro2A cell line T98G cell Human neuroblastoma Kelly cells(DSMZ) Human iPSC-derived cortical neurons CD-1 mouse gastrocnemius muscle CD-1 mouse serum Rat serum Chicken embryo myoblasts C₂C₁₂ cell Left lobe of the crab-eating macaque liver Right lobe of the crab-eating macaque liver Sprague Dawley rat Mus musculus Primary Macaque Hepatocytes C57BL/6 female mice LDL Receptor Knockout Mice Macaca mulatta Metabolic Syndrome Monkey ob/ob mouse model Human APOC3 Transgenic Mouse Hypertensive patient The C57BL/6 mice transduced with AAV expressing human AGT Female AGT transgenic mice Non-human hepatocytes RGA cell HelaS3 Unknown cell line

Modification Type:

All 2'-O-Methyladenosine 2'-O-Methyl-3'-Phosphorothioate adenosine 2'-O-Methyl-3'-Phosphorothioate guanosine 2'-Fluoro-3'-Phosphorothioate guanosine 2'-O-Methyl-3'-Phosphorothioate cytidine 2'-O-Methyluridine 2'-O-Methyl-3'-Phosphorothioate uridine 2'-O-Methylguanosine 2'-O-Methylcytidine 5'-Vinyl-(E)-phosphonate-2'-methoxyadenosine-3'-phosphorothioate 5'-Vinyl-(E)-phosphonate-2'-methoxyuridine-3'-phosphorothioate Adenosine-glycol nucleic acid Guanosine-glycol nucleic acid Uridine-glycol nucleic acid Locked Nucleic Acid in 2'-O-Methylcytidine Locked Nucleic Acid in Thymidine monophosphate Phosphorothioate-Locked Nucleic Acid in Thymidine monophosphate Locked Nucleic Acid in Adenosine monophosphate Locked Nucleic Acid in Guanosine monophosphate Phosphorothioate-Locked Nucleic Acid in Guanosine monophosphate Locked Nucleic Acid in Cytidine monophosphate 2'-Fluoroadenosine 2'-Fluorouridine 2'-Fluorocytidine 2'-Fluoroguanosine 2'-Deoxy-3'-Phosphorothioate adenosine 2'-Deoxy-3'-Phosphorothioate thymidine 2'-Deoxy-3'-Phosphorothioate cytidine 2'-Deoxy-3'-Phosphorothioate guanosine Reverse deoxythymidine Reverse deoxyadenosine Abasic-3'-Phosphorothioate Abasic 2'-Methoxyethyl adenosine 2'-Methoxyethyl cytidine 2'-Methoxyethyl uridine 2'-Methoxyethyl guanosine 2'-Methoxyethyl thymidine 2'-Methoxyethyl-3'-Phosphorothioate adenosine 2'-Methoxyethyl-3'-Phosphorothioate cytidine 2'-Methoxyethyl-3'-Phosphorothioate uridine 2'-Methoxyethyl-3'-Phosphorothioate guanosine 2'-Methoxyethyl-3'-Phosphorothioate thymidine Inverted abasic Inverted abasic-2'-O-Methyl-5'-Phosphorothioate cytidine Inverted abasic-2'-O-Methyl-5'-Phosphorothioate adenosine Adenosine modified with Unlocked Nucleic Acid Cytidine modified with Unlocked Nucleic Acid Guanosine modified with Unlocked Nucleic Acid Uridine modified with Unlocked Nucleic Acid Ethylene Glycol Nucleic Acid Thymidine (L)-α-threofuranosyl Uridine 2'-O-Methylinosine 3'-Thiophosphate-2'-O-Methylinosine 2'-O-hexadecyl adenosine 2'-O-hexadecyl uridine 2'-O-hexadecyl cytidine 2'-O-hexadecyl guanosine 2'-O-N-Methylacetamide adenosine 2'-O-N-Methylacetamide thymidine 2'-O-N-Methylacetamide cytidine 2'-O-N-Methylacetamide guanosine (R)-2'-deoxy-2'-fluoro-4'-thioadenosine (R)-2'-deoxy-2'-fluoro-4'-thio-5-methyluridine (R)-2'-deoxy-2'-fluoro-4'-thioguanosine (R)-2'-deoxy-2'-fluoro-4'-thiocytidine 2'-O-Methyl-3'-Phosphorothioate in the Sp configuration adenosine 2'-O-Methyl-3'-Phosphorothioate in the Sp configuration uridine 2'-O-Methyl-3'-Phosphorothioate in the Sp configuration cytidine 2'-O-Methyl-3'-Phosphorothioate in the Sp configuration guanosine 2'-O-Methyl-3'-Phosphorothioate in the Rp configuration adenosine 2'-O-Methyl-3'-Phosphorothioate in the Rp configuration uridine 2'-Fluoro-3'-Phosphorothioate in the Sp configuration guanosine 2'-Fluoro-3'-Phosphorothioate in the Rp configuration uridine 2'-Fluoro-3'-Phosphorothioate in the Rp configuration cytidine 2'-Fluoro-3'-Phosphorothioate in the Rp configuration guanosine 2'-Fluoroadenosine 2'-Fluorocytidine 2'-Fluorouridine 2'-Fluoroguanosine 2'-O-Methyladenosine 2'-O-Methyluridine 2'-O-Methylcytidine 2'-O-Methylguanosine 2'-O-Methyl-3'-Phosphorothioate adenosine 2'-O-Methyl-3'-Phosphorothioate uridine 2'-O-Methyl-3'-Phosphorothioate cytidine 2'-O-Methyl-3'-Phosphorothioate guanosine Abasic-3'-Phosphorothioate 5'-Phosphate ribose 5'-Phosphate ribose-2'-O-Methyl adenosine 5'-Phosphate ribose-2'-O-Methyl cytidine 5'-Phosphate ribose-2'-O-Methyl guanosine 5'-Phosphate ribose-2'-O-Methyl uridine 2'-Hydroxymethyl-Tetrahydrofuran-5'-Phosphate GalNAc3-Phosphorothioate

Modification locations:

All Base, Phosphate, Sugar Phosphate, Sugar Phosphate Sugar Base

Patent ID	Target Gene	Cell Type	Modification sequence information (include sense strand and antisense strand)	Inhibition	More