Detail information of Complex
Basic Information:
| Complex ID | CMCS00027 |
| Complex | VAPB; VAPA; OSBPL1A; RAB7A; RILP |
| Subunit Number | 5 |
| Membrane Contact Site |
ER-Endosome; Endosome-ER
|
| Species | Human |
| Identified PPI in BioGRID | VAPA-VAPB(LTP); VAPB-OSBPL1A(LTP); VAPA-OSBPL1A(LTP) |
Subunit Information:
| Subunit | Symbol | Uniprot ID | Subcellular location | More |
| subunit:1 | VAPA | Q9P0L0 | ER | more |
| subunit:2 | VAPB | O95292 | ER | more |
| subunit:3 | OSBPL1A | Q9BXW6 | Endosome | more |
| subunit:4 | RAB7A | P51149 | Endosome | more |
| subunit:5 | RILP | Q96NA2 | Endosome | more |
References:
| Pubmed ID | 19564404 |
| DOI | 10.1083/jcb.200811005 |
| Description | We show that cholesterol in LEs is sensed by ORP1L, which transmits this information to the Rab7–RILP–p150Glued complex through the formation of ER–LE membrane contact sites (MCSs). At these sites, the ER protein VAP enters the Rab7–RILP complex to control p150Glued binding and positioning of LEs. |
| More related results |