Basic Information:

Symbol	RILP
Synonyms	PP10141
Protein Name	Rab-interacting lysosomal protein
Species	Human
Entrez ID	29448
Uniprot ID	Q96NA2
Membrane Contact Site	ER-Endosome; Endosome-ER
Location (from literature)	Endosome
Cell line/Tissue	MelJuSo cells
Experimental Method	Low throughput experimental methods
Protein Sequence
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Complex Information:

Complex ID	Subunit of complex	Subcellular location	Species	More
CMCS00027	VAPB; VAPA; OSBPL1A; RAB7A; RILP	ER-Endosome; Endosome-ER	Human	more

Homology Information of RILP:

Uniprot ID	Q96NA2
EggNOG	ENOG502RXH1
HOGENOM	CLU_044133_1_0_1
OrthoDB	5400045at2759
TreeFam	TF313489
GeneTree	ENSGT00940000161117

References:

Pubmed ID	19564404
DOI	10.1083/jcb.200811005
Description	We show that cholesterol in LEs is sensed by ORP1L, which transmits this information to the Rab7–RILP–p150Glued complex through the formation of ER–LE membrane contact sites (MCSs). At these sites, the ER protein VAP enters the Rab7–RILP complex to control p150Glued binding and positioning of LEs.
Description of experimental evidence	The protein was validated by microscopy, FLIM, Immuno-EM and filipin stainings in MelJuSo cells, and these data explain how the ER and cholesterol control the association of LEs with motor proteins and their positioning in cells.
More related results