Basic Information:

Complex ID	CMCS00026
Complex	VAPB; VAPA; VPS13C
Subunit Number	3
Membrane Contact Site	ER-Endosome; Endosome-ER
Species	Human
Identified PPI in BioGRID	VAPB-VPS13C(HTP: 0.90); VAPA-VPS13C(HTP: 1.00); VAPA-VAPB(LTP)

Subunit Information:

Subunit	Symbol	Uniprot ID	Subcellular location	More
subunit:1	VAPB	O95292	ER	more
subunit:2	VAPA	Q9P0L0	ER	more
subunit:3	VPS13C	Q709C8	ER	more

References:

Pubmed ID	30093493
DOI	10.1083/jcb.201807019
Description	An FFAT motif, a short amino acid sequence known to interact with the ER VAMP-associated protein (VAP), is present in the Vps13α region of both proteins as previously noted.; These findings not only confirm the role of the FFAT motif in anchoring these proteins to the ER but also indicate that binding sites for mitochondria (in VPS13A), late endosomes/lysosomes (in VPS13C), and lipid droplets (both proteins) are localized in the C-terminal regions of the two proteins.
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