Detail Information of Protein
This page represents the latest version, and you may click to view the original version: Version 1.0
Basic Information:
| Symbol | VPS13C |
| Synonyms | KIAA1421 |
| Protein Name | Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) |
| Species | Human |
| Entrez ID | 54832 |
| Uniprot ID | Q709C8 |
| Membrane Contact Site |
ER-Endosome; Endosome-ER
|
| Location (from literature) | Endosome |
| Cell line/Tissue | HeLa cells; COS-7 cells; HEK293T cells |
| Experimental Method | Low throughput experimental methods |
| Protein Sequence | |
| More related results |
Complex Information:
| Complex ID | Subunit of complex | Subcellular location | Species | More |
| CMCS00026 | VAPB; VAPA; VPS13C | ER-Endosome; Endosome-ER | Human | more |
Homology Information of VPS13C:
| Uniprot ID | Q709C8 |
| EggNOG | KOG1809 |
| HOGENOM | CLU_000135_1_1_1 |
| OrthoDB | 199953at2759 |
| TreeFam | TF300316 |
| GeneTree | ENSGT00950000183083 |
References:
| Pubmed ID | 30093493 |
| DOI | 10.1083/jcb.201807019 |
| Description | Surprisingly, VPS13C, the paralogue most closely related to VPS13A, is instead localized at contacts between the ER and late endosomes or lysosomes, revealing that duplication of VPS13 during evolution correlates with diversification of their sites of action. |
| Description of experimental evidence | The protein was validated by bioinformatic analysis, mass spectrometry, FRET assays, correlative fluorescence, EM microscopy, Image processing, analysis and statistics in HeLa cells and COS-7 cells which has the lipid transport roles. |
| More related results |