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Basic Information:

Symbol	VPS13C
Synonyms	KIAA1421
Protein Name	Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C)
Species	Human
Entrez ID	54832
Uniprot ID	Q709C8
Membrane Contact Site	ER-Endosome; Endosome-ER
Location (from literature)	Endosome
Cell line/Tissue	HeLa cells; COS-7 cells; HEK293T cells
Experimental Method	Low throughput experimental methods
Protein Sequence
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Complex Information:

Complex ID	Subunit of complex	Subcellular location	Species	More
CMCS00026	VAPB; VAPA; VPS13C	ER-Endosome; Endosome-ER	Human	more

Expression Overview of VPS13C:

Homology Information of VPS13C:

Uniprot ID	Q709C8
EggNOG	KOG1809
HOGENOM	CLU_000135_1_1_1
OrthoDB	199953at2759
TreeFam	TF300316
GeneTree	ENSGT00950000183083

References:

Pubmed ID	30093493
DOI	10.1083/jcb.201807019
Description	Surprisingly, VPS13C, the paralogue most closely related to VPS13A, is instead localized at contacts between the ER and late endosomes or lysosomes, revealing that duplication of VPS13 during evolution correlates with diversification of their sites of action.
Description of experimental evidence	The protein was validated by bioinformatic analysis, mass spectrometry, FRET assays, correlative fluorescence, EM microscopy, Image processing, analysis and statistics in HeLa cells and COS-7 cells which has the lipid transport roles.
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Obsolete Reason	VPS13C silencing exacerbated PINK1/Parkin-mediated mitophagy.
Pubmed ID	26942284
DOI	10.1016/j.ajhg.2016.01.014
Description	Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrionl Dysfunction and Increases PINK1(Parkin) Dependent Mitophagy.
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