Basic Information:

Symbol	OSBPL10
Synonyms	ORP10; OSBP9
Protein Name	Oxysterol-binding protein-related protein 10 (ORP-10) (OSBP-related protein 10)
Species	Human
Entrez ID	114884
Uniprot ID	Q9BXB5
Membrane Contact Site	ER-Endosome; Endosome-ER
Location (from literature)	Endosome
Cell line/Tissue	HeLa cells; HEK293T cells; COS-7 cells
Experimental Method	Low throughput experimental methods
Protein Sequence
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Complex Information:

Complex ID	Subunit of complex	Subcellular location	Species	More
CMCS00167	OSBPL10; OSBPL9; VAPA; VAPB; PI(4)P	ER-Endosome; Endosome-ER	Human	more

Expression Overview of OSBPL10:

Homology Information of OSBPL10:

Uniprot ID	Q9BXB5
EggNOG	KOG2210
HOGENOM	CLU_012334_3_1_1
OrthoDB	1018068at2759
TreeFam	TF312807
GeneTree	ENSGT00940000157880

References:

Pubmed ID	34817532
DOI	10.1083/jcb.202103141
Description	In sum, our study demonstrates ORP10 as a novel PI4P(PS) exchanger at ER-endosome MCSs and the cellular role of ORP10 mediated lipid exchange.
Description of experimental evidence	The protein was validated by immunofluorescence microscopy, live-cell imaging, image analysis, coimmunoprecipitation and LC-MS/MS in HeLa cells, HEK293T cells and COS-7 cells, which is a new lipid exchanger at ER–endosome MCSs, and ORP10-mediated lipid conversion from PI4P to PS on endosomes controls retrograde membrane trafficking.
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