Basic Information:

Symbol	Gsk3b
Protein Name	Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Species	Mouse
Entrez ID	56637
Uniprot ID	Q9WV60
Membrane Contact Site	ER-MT; MT-ER
Location (from literature)	ER
Cell line/Tissue	Mouse T cell; Mouse testes
Experimental Method	Low throughput experimental methods
Protein Sequence
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Complex Information:

Complex ID	Subunit of complex	Subcellular location	Species	More
CMCS00177	Vdac1; Gsk3b	ER-MT; MT-ER	Mouse	more

Expression Overview of Gsk3b:

Homology Information of Gsk3b:

Uniprot ID	Q9WV60
EggNOG	KOG0658
HOGENOM	CLU_000288_181_20_1
OrthoDB	2872909at2759
TreeFam	TF101104
GeneTree	ENSGT00520000055635

References:

Pubmed ID	29523440
DOI	10.1016/j.immuni.2018.02.012
Description	Rapid activation of Akt by mTORC2 led to inhibition of Gsk-3b at mitochondria-ER junctions, enabling recruitment of hexokinase I (HK-I) to the mitochondrial channel, VDAC.
Description of experimental evidence	The protein was validated by metabolomics, flow cytometry, immunoblots, electron microscopy, proximity ligation assay and confocal imaging in neuronal mouse T cell, which underpins the metabolic reprogramming needed for memory CD8+ T cells to rapidly acquire effector function.
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Pubmed ID	29785746
DOI	10.1002/pmic.201700478
Description	By Andromeda search engine against the decoy UniProt-mouse database and Swiss-Prot human database, which yielded 2,808 proteins from mouse testes (mT),2,478 proteins from mouse brain (mB) and 2,155 proteins from human testes (hT).
Description of experimental evidence	The protein was validated by TEM and LC -MS/MS analyses in mouse testes.
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