Detail Information of Protein
Basic Information:
| Symbol | Sigmar1 |
| Synonyms | Oprs1 |
| Protein Name | Sigma non-opioid intracellular receptor 1 (Sigma 1-type opioid receptor) (Sigma1-receptor) (Sigma1R) |
| Species | Mouse |
| Entrez ID | 18391 |
| Uniprot ID | O55242 |
| Membrane Contact Site |
ER-MT; MT-ER
|
| Location (from literature) | ER |
| Cell line/Tissue | Neuro2a cells; Brown adipocytes; Mouse teste; Mouse brains |
| Experimental Method | Low throughput experimental methods |
| Protein Sequence | |
| More related results |
Complex Information:
| Complex ID | Subunit of complex | Subcellular location | Species | More |
| CMCS00078 | Sigmar1; Itpr3 | ER-MT; MT-ER | Mouse | more | CMCS00079 | Sigmar1; Sel1l; Syvn1 | ER-MT; MT-ER | Mouse | more |
Expression Overview of Sigmar1:
Homology Information of Sigmar1:
| Uniprot ID | O55242 |
| EggNOG | KOG4143 |
| HOGENOM | CLU_085469_0_0_1 |
| OrthoDB | 168990at2759 |
| TreeFam | TF300106 |
| GeneTree | ENSGT00390000012082 |
References:
| Pubmed ID | 27821430 |
| DOI | 10.15252/emmm.201606403 |
| Description | All these data indicate that the Sig1R activation that regulates IP3R3‐mediated intracellular Ca2+ flux at the MAM is crucial to prevent MAM disruption in motor neurons both in vitro and in vivo. |
| Description of experimental evidence | The protein was validated by rotarod test, immunofluorescence staining, electron microscopy, cycloheximide chase assay, co‐immunoprecipitation and neurotoxicity assay in Neuro2a cells, and the results indicate that collapse of the MAM is critical both in Sig1R ?and SOD1‐linked ALS. |
| More related results |
| Pubmed ID | 32193362 |
| DOI | 10.1126/science.aay2494 |
| Description | Sel1L-Hrd1 ERAD regulates MAM and Mitochondrionl dynamics via SigmaR1. |
| Description of experimental evidence | The protein was validated by western blot, histology, immunofluorescence, confocal microscopy, TEM, SBF-SEM, FIB-SEM, immunogold labeling, microarray analysis, RT-PCR, qPCR and IP in brown adipocytes, and this study may have implications not only for interorganelle communication, but also for the pathophysiological role of Sel1L-Hrd1 ERAD. |
| More related results |
| Pubmed ID | 29785746 |
| DOI | 10.1002/pmic.201700478 |
| Description | Calnexin, Calreticulin and Sigmar1R are three commonly acknowledged MAM and ER markers, which all presented at comparable levels in our isolated MAM and ER fractions. |
| Description of experimental evidence | The protein was validated by TEM and LC -MS/MS analyses in mouse testes and mouse brains. |
| More related results |