Basic Information:

Symbol	KIF5B
Synonyms	KNS; KNS1
Protein Name	Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC)
Species	Human
Entrez ID	3799
Uniprot ID	P33176
Membrane Contact Site	ER-Endosome; Endosome-ER
Location (from literature)	ER
Cell line/Tissue	HeLa cells; hTERT-RPE1 cells; HL60 cells; HEK293 cells
Experimental Method	Low throughput experimental methods
Protein Sequence
More related results

Complex Information:

Complex ID	Subunit of complex	Subcellular location	Species	More
CMCS00006	ZFYVE27; FYCO1; KIF5B; RAB7A; PI(3)P	ER-Endosome; Endosome-ER	Human	more

Expression Overview of KIF5B:

Homology Information of KIF5B:

Uniprot ID	P33176
EggNOG	KOG0240
HOGENOM	CLU_001485_11_1_1
OrthoDB	5476186at2759
TreeFam	TF105225
GeneTree	ENSGT00940000154801

References:

Pubmed ID	25855459
DOI	10.1038/nature14359
Description	Here we show in human and rat cell lines that protrudin, an ER protein that promotes protrusion and neurite outgrowth, forms contact sites with late endosomes (LEs) via coincident detection of the small GTPase RAB7 and phosphatidylinositol 3-phosphate (PtdIns(3)P). These contact sites mediate transfer of the microtubule motor kinesin 1 from protrudin to the motor adaptor FYCO1 on LEs.
Description of experimental evidence	The protein was validated by microscopy, western blotting, GFP-trap assay, in HeLa cells,hTERT-RPE1 cells, hTERT-RPE1 cells and HL60 cells, and these results correlate strongly with the cooperative effects of protrudin and FYCO1 in protrusion and neurite outgrowth
More related results