Basic Information:

Symbol	NPC1
Protein Name	NPC intracellular cholesterol transporter 1 (Niemann-Pick C1 protein)
Species	Human
Entrez ID	4864
Uniprot ID	O15118
Membrane Contact Site	ER-Endosome; Endosome-ER
Location (from literature)	Endosome
Cell line/Tissue	CHO-K1 cells; HeLa cells; HEK293 cells;
Experimental Method	Low throughput experimental methods
Protein Sequence
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Complex Information:

Complex ID	Subunit of complex	Subcellular location	Species	More
CMCS00003	OSBPL5; NPC1	ER-Endosome; Endosome-ER	Human	more
CMCS00004	VAPA; OSBPL1A; sterol; PI(4)P; NPC1	ER-Endosome; Endosome-ER	Human	more

Expression Overview of NPC1:

Homology Information of NPC1:

Uniprot ID	O15118
EggNOG	KOG1933
HOGENOM	/
OrthoDB	2786103at2759
TreeFam	TF300416
GeneTree	ENSGT00940000156182

References:

Pubmed ID	21220512
DOI	10.1083/jcb.201004142
Description	Our results suggest that ORP5 may cooperate with NPC1 to deliver cholesterol from LE/LY to the ER.
Description of experimental evidence	The protein was validated by filipin staining, fluorescence microscopy, immunofluorescence, confocal microscopy, coimmunoprecipitation, GST pull-down assay and immunoblot analysis in CHO-K1 cells, HeLa cells, HEK293 cells and Npc1-null2-2 cells.
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Pubmed ID	28564600
DOI	10.1016/j.celrep.2017.05.028
Description	Cholesterol delivery to the ER required the sterol-, phosphatidylinositol 4-phosphate-, and vesicle-associated membrane protein-associated protein (VAP)-binding activities of ORP1L, as well as NPC1 expression.
Description of experimental evidence	The protein was validated by PCR analysis, immunoblotting, immunoprecipitation, fluorescence and electron microscopy in HeLa cells and HEK293 cells, which regulates Cholesterol Egress from the Endo-Lysosomal System.
More related results