Detail Information of Protein
Basic Information:
| Symbol | Park7 |
| Synonyms | DJ-1 |
| Protein Name | Parkinson disease protein 7 homolog (Maillard deglycase) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124) |
| Species | Mouse |
| Entrez ID | 57320 |
| Uniprot ID | Q99LX0 |
| Membrane Contact Site |
ER-MT; MT-ER
|
| Location (from literature) | ER; MT |
| Cell line/Tissue | C57BL6 mice; Mouse testes; Mouse brains and retinas; RGCs; HRECs |
| Experimental Method | Low throughput experimental methods |
| Protein Sequence | |
| More related results |
Complex Information:
| Complex ID | Subunit of complex | Subcellular location | Species | More |
| CMCS00107 | Itpr3; Hspa9; Vdac1; Park7 | ER-MT; MT-ER | Mouse | more |
Expression Overview of Park7:
Homology Information of Park7:
| Uniprot ID | Q99LX0 |
| EggNOG | KOG2764 |
| HOGENOM | CLU_000445_44_2_1 |
| OrthoDB | 1117759at2759 |
| TreeFam | TF300119 |
| GeneTree | ENSGT00390000001231 |
References:
| Pubmed ID | 31767755 |
| DOI | 10.1073/pnas.1906565116 |
| Description | DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-GRP75-VDAC1. |
| Description of experimental evidence | The protein was validated by western blotting, electron microscopy, co-immunoprecipitation assays, PLA, Blue-Native and SDS-PAGE 2D separation in C57BL6 mice, and suggests that impaired ER-mitochondria association could contribute to the pathogenesis of PD. |
| More related results |
| Pubmed ID | 29785746 |
| DOI | 10.1002/pmic.201700478 |
| Description | By Andromeda search engine against the decoy UniProt-mouse database and Swiss-Prot human database, which yielded 2,808 proteins from mouse testes (mT),2,478 proteins from mouse brain (mB) and 2,155 proteins from human testes (hT). |
| Description of experimental evidence | The protein was validated by TEM and LC -MS/MS analyses in mouse testes and mouse brains. |
| More related results |
| Pubmed ID | 28522876 |
| DOI | 10.1038/s41598-017-02213-1 |
| Description | Using this method, 1313 non-redundant proteins were identified in the MAM. |
| Description of experimental evidence | The protein was validated by proteomic analysis, long gradient nano-reverse-phase liquid chromatography, mass spectrometry and bioinformatics analysis in RGCs, HRECs, mouse brains and retinas. |
| More related results |