Detail Information of Protein
Basic Information:
| Symbol | Syvn1 |
| Synonyms | Hrd1; Kiaa1810 |
| Protein Name | E3 ubiquitin-protein ligase synoviolin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase synoviolin) (Synovial apoptosis inhibitor 1) |
| Species | Mouse |
| Entrez ID | 74126 |
| Uniprot ID | Q9DBY1 |
| Membrane Contact Site |
ER-MT; MT-ER
|
| Location (from literature) | ER |
| Cell line/Tissue | Brown adipocytes |
| Experimental Method | Low throughput experimental methods |
| Protein Sequence | |
| More related results |
Complex Information:
| Complex ID | Subunit of complex | Subcellular location | Species | More |
| CMCS00079 | Sigmar1; Sel1l; Syvn1 | ER-MT; MT-ER | Mouse | more |
Expression Overview of Syvn1:
Homology Information of Syvn1:
| Uniprot ID | Q9DBY1 |
| EggNOG | KOG0802 |
| HOGENOM | / |
| OrthoDB | 2912447at2759 |
| TreeFam | TF318635 |
| GeneTree | / |
References:
| Pubmed ID | 32193362 |
| DOI | 10.1126/science.aay2494 |
| Description | Sel1L-Hrd1 ERAD regulates MAM and Mitochondrionl dynamics via SigmaR1. |
| Description of experimental evidence | The protein was validated by western blot, histology, immunofluorescence, confocal microscopy, TEM, SBF-SEM, FIB-SEM, immunogold labeling, microarray analysis, RT-PCR, qPCR and IP in brown adipocytes, and this study may have implications not only for interorganelle communication, but also for the pathophysiological role of Sel1L-Hrd1 ERAD. |
| More related results |