Detail Information of Protein
Basic Information:
| Symbol | Pdk4 |
| Protein Name | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4) |
| Species | Mouse |
| Entrez ID | 27273 |
| Uniprot ID | O70571 |
| Membrane Contact Site |
ER-MT; MT-ER
|
| Location (from literature) | MT |
| Cell line/Tissue | C2C12 myoblasts |
| Experimental Method | Low throughput experimental methods |
| Protein Sequence | |
| More related results |
Complex Information:
| Complex ID | Subunit of complex | Subcellular location | Species | More |
| CMCS00266 | Itpr3; Hspa9; Vdac1; Pdk4 | ER-MT; MT-ER | Mouse | more |
Expression Overview of Pdk4:
Homology Information of Pdk4:
| Uniprot ID | O70571 |
| EggNOG | KOG0787 |
| HOGENOM | CLU_023861_1_1_1 |
| OrthoDB | 3058550at2759 |
| TreeFam | TF314918 |
| GeneTree | ENSGT01030000234646 |
References:
| Pubmed ID | 30523025 |
| DOI | 10.2337/db18-0363 |
| Description | Here, we demonstrate that PDK4 interacts with and stabilizes the IP3R1-GRP75-VDAC1 complex at the MAM interface. |
| Description of experimental evidence | The protein was validated by in situ proximity ligation assay, immunofluorescence analysis, coimmunoprecipitation, transmission electron microscopy and immunoblotting in C2C12 myoblasts, which augments ER–Mitochondria contact to dampen skeletal muscle insulin signaling during obesity. |
| More related results |