Basic Information:

Symbol	OSBP
Synonyms	OSBP1
Protein Name	Oxysterol-binding protein 1
Species	Human
Entrez ID	5007
Uniprot ID	P22059
Membrane Contact Site	ER-Endosome; Endosome-ER
Location (from literature)	ER
Cell line/Tissue	HeLa cells; COS-7 cells
Experimental Method	Low throughput experimental methods
Protein Sequence
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Complex Information:

Complex ID	Subunit of complex	Subcellular location	Species	More
CMCS00009	VAPA; VAPB; OSBP; PI(4)P	ER-Endosome; Endosome-ER	Human	more

Expression Overview of OSBP:

Homology Information of OSBP:

Uniprot ID	P22059
EggNOG	KOG1737
HOGENOM	CLU_007105_5_0_1
OrthoDB	960at2759
TreeFam	TF320922
GeneTree	ENSGT00940000156164

References:

Pubmed ID	27419871
DOI	10.1016/j.cell.2016.06.037
Description	Defects are mimicked by downregulation of OSBP, a VAP interactor and PI4P transporter that participates in VAP-dependent ER-endosomes tethers.
Description of experimental evidence	The protein was validated by TALENs, fluorescence microscopy, western blotting and phosphoinositide analysis in HeLa cells, COS-7 cells, and these results reveal a role of PI5P in retromer-/WASH-dependent budding from endosomes.
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