Detail Information of Protein
Basic Information:
| Symbol | OSBP |
| Synonyms | OSBP1 |
| Protein Name | Oxysterol-binding protein 1 |
| Species | Human |
| Entrez ID | 5007 |
| Uniprot ID | P22059 |
| Membrane Contact Site |
ER-Endosome; Endosome-ER
|
| Location (from literature) | ER |
| Cell line/Tissue | HeLa cells; COS-7 cells |
| Experimental Method | Low throughput experimental methods |
| Protein Sequence | |
| More related results |
Complex Information:
| Complex ID | Subunit of complex | Subcellular location | Species | More |
| CMCS00009 | VAPA; VAPB; OSBP; PI(4)P | ER-Endosome; Endosome-ER | Human | more |
Homology Information of OSBP:
| Uniprot ID | P22059 |
| EggNOG | KOG1737 |
| HOGENOM | CLU_007105_5_0_1 |
| OrthoDB | 960at2759 |
| TreeFam | TF320922 |
| GeneTree | ENSGT00940000156164 |
References:
| Pubmed ID | 27419871 |
| DOI | 10.1016/j.cell.2016.06.037 |
| Description | Defects are mimicked by downregulation of OSBP, a VAP interactor and PI4P transporter that participates in VAP-dependent ER-endosomes tethers. |
| Description of experimental evidence | The protein was validated by TALENs, fluorescence microscopy, western blotting and phosphoinositide analysis in HeLa cells, COS-7 cells, and these results reveal a role of PI5P in retromer-/WASH-dependent budding from endosomes. |
| More related results |