Basic Information:

Symbol	OSBPL5
Synonyms	KIAA1534; OBPH1; ORP5
Protein Name	Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1)
Species	Human
Entrez ID	114879
Uniprot ID	Q9H0X9
Membrane Contact Site	ER-Endosome; Endosome-ER
Location (from literature)	ER
Cell line/Tissue	CHO-K1 cells; HeLa cells; HEK293 cells
Experimental Method	Low throughput experimental methods
Protein Sequence
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Complex Information:

Complex ID	Subunit of complex	Subcellular location	Species	More
CMCS00003	OSBPL5; NPC1	ER-Endosome; Endosome-ER	Human	more

Expression Overview of OSBPL5:

Homology Information of OSBPL5:

Uniprot ID	Q9H0X9
EggNOG	KOG2210
HOGENOM	CLU_012334_2_1_1
OrthoDB	1018068at2759
TreeFam	TF312807
GeneTree	ENSGT00940000159535

References:

Pubmed ID	21220512
DOI	10.1083/jcb.201004142
Description	Our results suggest that ORP5 may cooperate with NPC1 to deliver cholesterol from LE/LY to the ER.
Description of experimental evidence	The protein was validated by filipin staining, fluorescence microscopy, immunofluorescence, confocal microscopy, coimmunoprecipitation, GST pull-down assay and immunoblot analysis in CHO-K1 cells, HeLa cells, HEK293 cells and Npc1-null2-2 cells.
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