Detail Information of Protein
Basic Information:
| Symbol | OSBPL5 |
| Synonyms | KIAA1534; OBPH1; ORP5 |
| Protein Name | Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1) |
| Species | Human |
| Entrez ID | 114879 |
| Uniprot ID | Q9H0X9 |
| Membrane Contact Site |
ER-Endosome; Endosome-ER
|
| Location (from literature) | ER |
| Cell line/Tissue | CHO-K1 cells; HeLa cells; HEK293 cells |
| Experimental Method | Low throughput experimental methods |
| Protein Sequence | |
| More related results |
Complex Information:
| Complex ID | Subunit of complex | Subcellular location | Species | More |
| CMCS00003 | OSBPL5; NPC1 | ER-Endosome; Endosome-ER | Human | more |
Homology Information of OSBPL5:
| Uniprot ID | Q9H0X9 |
| EggNOG | KOG2210 |
| HOGENOM | CLU_012334_2_1_1 |
| OrthoDB | 1018068at2759 |
| TreeFam | TF312807 |
| GeneTree | ENSGT00940000159535 |
References:
| Pubmed ID | 21220512 |
| DOI | 10.1083/jcb.201004142 |
| Description | Our results suggest that ORP5 may cooperate with NPC1 to deliver cholesterol from LE/LY to the ER. |
| Description of experimental evidence | The protein was validated by filipin staining, fluorescence microscopy, immunofluorescence, confocal microscopy, coimmunoprecipitation, GST pull-down assay and immunoblot analysis in CHO-K1 cells, HeLa cells, HEK293 cells and Npc1-null2-2 cells. |
| More related results |