Overview:
The current version of MetaboliteCOVID records 665 data related to COVID-19 metabolites found manually, including their naming, chemical structure, 2D structure diagram, etc., as well as related information of literature and corresponding patients. According to indication, these data can be divided into four categories: Disease biomarker, Severity marker, Drugs response,and Prognostic marker. MetaboliteCOVID also offers a number of data visualization and analysis tools that help users better understand and analyze data. In summary, MetaboliteCOVID is designed to enable users to quickly and easily query, browse, and visualize relevant information, and it also hints at the importance of certain differential metabolites for maintaining biological health.
The homepage is displayed in the following Fig 1-1:
1. Main functions of the database are provided in menu bar form (boxed in red).
2. Introduction and overview for MetaboliteCOVID.
3. Quick search for users.
Fig 1-1. Home page
The search page is displayed in Fig 2-1 and 2-2:
Exact search:
1. Select exact search.
2. Select type of input keyword: two choices are provided (Metabolite Name/Pubchem CID).
3. Input a keyword corresponding to selected type.
4. Select the specimen to filter the search (3 specimen: Plasma, Saliva and Serum).
5. Select the indication to filter the search (4 indication: Disease biomarker, Drugs response, Prognostic marker and Severity marker).
Fig 2-1. Exact Search page
Batch search:
1. Select batch search.
2. Select type of input keyword: two choices are provided (Metabolite Name/Pubchem CID).
3. Input list of keywords corresponding to selected type.
4. Select the specimen to filter the search (3 specimen: Plasma, Saliva and Serum).
5. Select the indication to filter the search (4 indication: Disease biomarker, Drugs response, Prognostic marker and Severity marker).
Fig 2-2. Batch Search page
Result page of Exact search and Batch search:
For the result page of Exact search and Batch search, all entries are listed with basic information including Metabolite Name, Pubchem CID, Specimen, Technology, Indication.
Fig 3-1：
1. Search keyword from the result table.
2. The result table (including Metabolite Name, Pubchem CID, Specimen, Technology, Indication).
3. Click to link to Detail page.
Fig 3-1. Result page of Exact search and Batch search
In the Detail page, you can get the detail information of the related metabolite including “Basic Information”, “Sample Data (Sample Quantity, Sample Group, Specimen, Technology, Comparison Group, Upregulated/Downregulated and Indication)” and “References”.
Fig 4-1:
1. Basic Information: including Metabolite Name, Metabolite Chemical Formula, PubChem CID, PubChem SID, Metabolite Smiles and Metabolite Structure.
2. Sample Data: Sample Quantity, Specimen, Technology, Comparison Group, Upregulated/Downregulated and Indication.
3. References: the PMID, Title, journal and published years of the references.
Fig 4-1. Detail page
The metabolite list was presented in the Browse page, Users can browse all the metabolites by three filter ways: by Specimen, by Technology and by Indication.
Fig 5-1:
1. Filter by specimen (3 specimen: Plasma, Saliva and Serum).
2. Filter by detected technology (11 type of Technology).
3. Filter by indication (4 indication: Disease biomarker, Prognostic marker, Drugs response and Severity marker).
4. The result table.
Fig 5-1. Browse page
MetaboliteCOVID provide the download page for users. You can download all the metabolites and sample data in the download page.
Fig 6-1. Download page